Cadaveric cardiosphere-derived cells can maintain regenerative capacity and improve the heart function of cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Cardiosphere-derived cells for heart regeneration.
www.thelancet.com Vol 379 June 30, 2012 2425 2 Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science 2008; 319: 91–93. 3 Lemos B, Branco AT, Hartl DL. Epigenetic eff ects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual confl ict. Proc Natl Acad Sci USA 2010; 107: 15826–31. 4 Spach ...
متن کاملCardiosphere-Derived Cells Improve Function in the Infarcted Rat Heart for at Least 16 Weeks – an MRI Study
AIMS Endogenous cardiac progenitor cells, expanded from explants via cardiosphere formation, present a promising cell source to prevent heart failure following myocardial infarction. Here we used cine-magnetic resonance imaging (MRI) to track administered cardiosphere-derived cells (CDCs) and to measure changes in cardiac function over four months in the infarcted rat heart. METHODS AND RESUL...
متن کاملRegenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.
BACKGROUND Ex vivo expansion of resident cardiac stem cells, followed by delivery to the heart, may favor regeneration and functional improvement. METHODS AND RESULTS Percutaneous endomyocardial biopsy specimens grown in primary culture developed multicellular clusters known as cardiospheres, which were plated to yield cardiosphere-derived cells (CDCs). CDCs from human biopsy specimens and fr...
متن کاملCardiac regenerative potential of cardiosphere-derived cells from adult dog hearts
The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs...
متن کاملEngraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy.
BACKGROUND Cardiosphere-derived cells (CDCs) isolated from human endomyocardial biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing in large animals is necessary for clinical translation. METHODS AND RESULTS Mesenchymal stem cells, which resemble CDCs in size and thrombogenicity, have been associated with infarction after intracoronary infusion. To m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2016
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2016.1160973